Andreas Seppi defeated Denis Istomin 6-4 3-6 6-3 in the Rome Masters round of 64 on clay. The result followed the form book — Andreas Seppi came in leading the head-to-head 6–4, defending last year's round of 64. Andreas Seppi extended the head-to-head to 7–4.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2018-06-25 | Eastbourne | R32 | grass | Denis Istomin | 6-3 6-7(4) 7-6(4) |
| 2016-01-11 | Sydney | R32 | hard | Andreas Seppi | 6-4 4-6 6-2 |
| 2015-01-19 | Australian Open | R128 | hard | Andreas Seppi | 5-7 6-3 2-6 6-1 6-4 |
| 2014-05-18 | Dusseldorf | QF | clay | Denis Istomin | 6-3 6-4 |
| 2013-08-26 | US Open | R32 | hard | Denis Istomin | 6-3 6-4 2-6 3-6 6-1 |
| 2013-06-24 | Wimbledon | R128 | grass | Andreas Seppi | 7-6(6) 7-6(3) 5-7 3-6 6-3 |
| 2013-01-14 | Australian Open | R64 | hard | Andreas Seppi | 7-6(4) 5-7 6-7(3) 7-6(3) 6-2 |
| 2012-06-25 | Wimbledon | R128 | grass | Denis Istomin | 6-7(2) 6-4 3-6 6-3 8-6 |
| 2011-07-31 | Kitzbuhel | R32 | clay | Andreas Seppi | 6-2 6-2 |
| 2011-01-10 | Sydney | R32 | hard | Andreas Seppi | 6-1 6-0 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About