John Isner defeated Stan Wawrinka 6-7 7-5 7-6 in the Paris Masters round of 64 on hard. John Isner extended the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2020-01-20 | Australian Open | R32 | hard | Stan Wawrinka | 6-4 4-1 RET |
| 2017-05-15 | Rome Masters | R16 | clay | John Isner | 7-6(1) 6-4 |
| 2010-05-03 | Belgrade | SF | hard | John Isner | 7-5 7-5 |
| 2009-10-05 | Tokyo | R32 | hard | Stan Wawrinka | 6-4 6-4 |
Averages from each player's recent completed matches (20 vs 19). ATP, WTA & Challenger.