Radek Stepanek defeated John Isner 7-5 5-7 7-6 in the Cincinnati Masters round of 64 on hard. Radek Stepanek extended the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2015-07-27 | Atlanta | R16 | hard | John Isner | 7-6 7-6 |
| 2012-10-07 | Shanghai Masters | R16 | hard | Radek Stepanek | 6-4 6-7 6-3 |
| 2011-01-17 | Australian Open | R64 | hard | John Isner | 4-6 6-4 6-2 6-1 |
| 2008-06-16 | Nottingham | R32 | grass | Radek Stepanek | 6-3 6-2 |
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About