Guillermo Garcia Lopez advanced when Andy Roddick retired 3-6 3-2 in the Shanghai Masters round of 32. Guillermo Garcia Lopez claimed a first win over Andy Roddick in three meetings, narrowing the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2008-02-18 | San Jose | SF | hard | Andy Roddick | 7-6(2) 6-1 |
| 2006-02-13 | San Jose | R32 | hard | Andy Roddick | 6-3 6-4 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.