Roger Federer defeated John Isner 6-3 6-4 in the Shanghai Masters round of 32 on hard. The result followed the form book — Roger Federer came in leading the head-to-head 7–2. Roger Federer extended the head-to-head to 8–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2019-09-20 | Laver Cup | RR | hard | Roger Federer | 6-4 7-6 |
| 2019-03-18 | Miami Masters | F | hard | Roger Federer | 6-1 6-4 |
| 2018-09-21 | Laver Cup | RR | hard | Roger Federer | 6-7 7-6 |
| 2015-11-02 | Paris Masters | R16 | hard | John Isner | 7-6 3-6 7-6 |
| 2015-08-31 | US Open | R16 | hard | Roger Federer | 7-6 7-6 7-5 |
| 2012-07-25 | London Olympics | QF | grass | Roger Federer | 6-4 7-6 |
| 2012-03-08 | Indian Wells Masters | F | hard | Roger Federer | 7-6 6-3 |
| 2012-02-10 | Davis Cup WG R1: SUI vs USA | RR | hard | John Isner | 4-6 6-3 7-6 6-2 |
| 2007-08-27 | US Open | R32 | hard | Roger Federer | 6-7 6-2 6-4 6-2 |
Averages over each player's completed matches in the selected window (199 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About