Guillermo Garcia Lopez defeated Tomas Berdych 7-6 6-3 in the Shanghai Masters round of 16 on hard. The upset overturned the form book — Tomas Berdych came in leading the head-to-head 5–2, defending last year's round of 16. Guillermo Garcia Lopez narrowed the head-to-head to 5–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2018-01-15 | Australian Open | R64 | hard | Tomas Berdych | 6-3 2-6 6-2 6-3 |
| 2015-09-28 | Shenzhen | F | hard | Tomas Berdych | 6-3 7-6(7) |
| 2015-08-31 | US Open | R32 | hard | Tomas Berdych | 6-7(2) 7-6(7) 6-3 6-3 |
| 2014-04-13 | Monte Carlo Masters | R16 | clay | Guillermo Garcia Lopez | 4-6 6-3 6-1 |
| 2011-02-07 | Rotterdam | R32 | hard | Tomas Berdych | 6-1 6-2 |
| 2009-05-10 | Madrid Masters | R64 | clay | Tomas Berdych | 6-0 7-6(5) |
| 2007-05-28 | Roland Garros | R128 | clay | Guillermo Garcia Lopez | 7-5 6-4 6-4 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.