Rafael Nadal defeated Denis Istomin 6-2 7-6 7-5 in the US Open round of 64 on hard. The result followed the form book — Rafael Nadal came in leading the head-to-head 4–0, defending last year's semi-final. Rafael Nadal extended the head-to-head to 5–0.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2016-08-29 | US Open | R128 | hard | Rafael Nadal | 6-1 6-4 6-2 |
| 2014-03-19 | Miami Masters | R32 | hard | Rafael Nadal | 6-1 6-0 |
| 2012-05-27 | Roland Garros | R64 | clay | Rafael Nadal | 6-2 6-2 6-0 |
| 2010-06-07 | Queen's Club | R16 | grass | Rafael Nadal | 7-6(4) 4-6 6-4 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About