Fernando Verdasco defeated John Isner 4-6 6-4 6-4 6-4 in the US Open round of 16 on hard. The upset overturned the form book — John Isner came in leading the head-to-head 2–0, defending last year's round of 128. Fernando Verdasco claimed a first win over John Isner in three meetings, narrowing the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-02-21 | Acapulco | R32 | hard | John Isner | 7-5 6-7(4) 7-6(3) |
| 2014-03-06 | Indian Wells Masters | R16 | hard | John Isner | 7-6(3) 3-6 6-3 |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About