Mikhail Youzhny defeated Andreas Seppi 7-6 6-3 in the Marseille round of 16 on hard. The result followed the form book — Mikhail Youzhny came in leading the head-to-head 4–3, defending last year's quarter-final. Mikhail Youzhny extended the head-to-head to 5–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2018-04-23 | Budapest | R16 | clay | Andreas Seppi | 6-1 6-2 |
| 2018-02-05 | Sofia | R32 | hard | Andreas Seppi | 6-3 6-4 |
| 2014-08-10 | Cincinnati Masters | R32 | hard | Mikhail Youzhny | 6-3 6-4 |
| 2014-04-13 | Monte Carlo Masters | R64 | clay | Andreas Seppi | 6-3 7-6(4) |
| 2008-07-21 | Canada Masters | R64 | hard | Mikhail Youzhny | 7-6(1) 6-2 |
| 2008-01-14 | Australian Open | R64 | hard | Mikhail Youzhny | 4-6 7-5 6-3 7-6(4) |
| 2006-05-08 | Rome Masters | R64 | clay | Mikhail Youzhny | 6-2 7-6(7) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About