Ivo Karlovic defeated Novak Djokovic 7-6 7-6 in the Madrid Masters round of 16 on clay. Ivo Karlovic extended the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2015-01-05 | Doha | QF | hard | Ivo Karlovic | 6-7(2) 7-6(6) 6-4 |
| 2008-05-11 | Hamburg Masters | R16 | clay | Novak Djokovic | 7-6(3) 6-3 |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.