Ivo Karlovic defeated John Isner 6-7 6-3 6-4 in the New Haven round of 32 on hard. Ivo Karlovic extended the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2014-02-24 | Acapulco | R32 | hard | Ivo Karlovic | 7-6(4) 7-6(5) |
| 2013-07-08 | Newport | QF | grass | John Isner | 7-6(3) 7-6(3) |
| 2011-04-04 | Houston | QF | clay | Ivo Karlovic | 7-6(2) 6-7(2) 7-6(9) |
| 2010-02-15 | Memphis | QF | hard | John Isner | 6-1 7-6(7) |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About