Mardy Fish defeated Ivo Karlovic 7-6 6-4 in the New Haven semi-final on hard. The upset overturned the form book — Ivo Karlovic came in leading the head-to-head 5–0, defending last year's round of 64, but Mardy Fish had been the form player, winning 2 of their last 6 on hard. Mardy Fish claimed a first win over Ivo Karlovic in six meetings, narrowing the head-to-head to 5–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2010-02-22 | Delray Beach | SF | hard | Ivo Karlovic | 6-2 6-3 |
| 2007-06-11 | Queen's Club | R64 | grass | Ivo Karlovic | 6-3 6-4 |
| 2007-02-12 | San Jose | QF | hard | Ivo Karlovic | 7-6(2) 6-4 |
| 2005-08-29 | US Open | R128 | hard | Ivo Karlovic | 7-6(4) 6-3 5-7 7-6(4) |
| 2004-01-19 | Australian Open | R128 | hard | Ivo Karlovic | 7-6(0) 7-6(5) 7-6(4) |
Averages from each player's recent completed matches (20 vs 20). ATP, WTA & Challenger.