David Marrero defeated Pablo Santos 7-5 5-7 7-6 in the Spain F6 qualifying round on clay. David Marrero extended the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2006-03-06 | Egypt F1 | QF | clay | Pablo Santos | 6-4 6-4 |
| 2006-02-06 | Spain F5 | F | clay | Pablo Santos | 6-3 3-0 |
| 2004-08-30 | Spain F21 | R32 | clay | David Marrero | 3-1 |
| 2004-08-23 | Spain F20 | SF | clay | David Marrero | 7-6(8) 6-2 |
Averages over each player's completed matches in the selected window. ATP, WTA & Challenger.