Daniela Hantuchova defeated Serena Williams 6-1 7-6 in the Australian Open round of 32 on hard. The upset overturned the form book — Serena Williams came in leading the head-to-head 9–0, defending the title. Daniela Hantuchova claimed a first win over Serena Williams in ten meetings, narrowing the head-to-head to 9–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2014-01-13 | Australian Open | R32 | hard | Serena Williams | 6-3 6-3 |
| 2009-08-31 | US Open | R16 | hard | Serena Williams | 6-2 6-0 |
| 2009-06-22 | Wimbledon | R16 | grass | Serena Williams | 6-3 6-1 |
| 2007-06-25 | Wimbledon | R16 | grass | Serena Williams | 6-2 6-7 6-2 |
| 2006-08-28 | US Open | R64 | hard | Serena Williams | 7-5 6-3 |
| 2006-08-07 | Los Angeles | R16 | hard | Serena Williams | 1-6 6-3 6-3 |
| 2005-02-28 | Dubai | QF | hard | Serena Williams | 6-4 6-3 |
| 2002-08-26 | US Open | QF | hard | Serena Williams | 6-2 6-2 |
| 2002-06-24 | Wimbledon | QF | grass | Serena Williams | 6-3 6-2 |
Averages over each player's completed matches in the selected window (200 vs 198). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About