Roger Federer defeated Denis Istomin 6-2 6-3 6-2 in the Australian Open round of 128 on hard. The result followed the form book — Roger Federer came in leading the head-to-head 7–0, defending last year's semi-final. Roger Federer extended the head-to-head to 8–0.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2021-05-31 | Roland Garros | R128 | clay | Roger Federer | 6-2 6-4 6-3 |
| 2019-01-14 | Australian Open | R128 | hard | Roger Federer | 6-3 6-4 6-4 |
| 2014-10-20 | Basel | R16 | hard | Roger Federer | 3-6 6-3 6-4 |
| 2013-10-21 | Basel | R16 | hard | Roger Federer | 4-6 6-3 6-2 |
| 2013-03-07 | Indian Wells Masters | R64 | hard | Roger Federer | 6-2 6-3 |
| 2012-07-25 | London Olympics | R16 | grass | Roger Federer | 7-5 6-3 |
| 2010-08-15 | Cincinnati Masters | R32 | hard | Roger Federer | 5-2 RET |
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About