Serena Williams defeated Irina Spirlea 6-2 6-3 in the Rome round of 16 on clay. The result followed the form book — Serena Williams came in leading the head-to-head 2–1, defending last year's quarter-final. Serena Williams extended the head-to-head to 3–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 1998-08-31 | US Open | R32 | hard | Irina Spirlea | 6-3 0-6 7-5 |
| 1998-03-19 | Key Biscayne | R64 | hard | Serena Williams | 7-6 6-0 |
| 1998-01-19 | Australian Open | R128 | hard | Serena Williams | 6-7(5) 6-3 6-1 |
Averages over each player's completed matches in the selected window. ATP, WTA & Challenger.