Serena Williams defeated Nathalie Tauziat 7-5 6-0 in the Rome round of 64 on clay. The upset overturned the form book — Nathalie Tauziat came in defending last year's round of 32. Serena Williams extended the head-to-head to 2–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2000-02-07 | Paris | F | carpet | Nathalie Tauziat | 7-5 6-2 |
| 1999-02-22 | Paris | R16 | carpet | Serena Williams | 6-1 6-4 |
Averages over each player's completed matches in the selected window. ATP, WTA & Challenger.